Laboratory for Behavioral Neurophysiology of Memory



Differential encoding of place value between the dorsal and intermediate hippocampus
Year of publication 2021
Title of paper Differential encoding of place value between the dorsal and intermediate hippocampus
Author Jin S.W. and Lee I.
Publication in journal Current Biology
Status of publication published
Vol 31, 3053-3072
File 첨부 JinLee Curr Biol 2021.pdf (17.3M) 37회 다운로드 DATE : 2021-05-28 09:37:23
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Neuroscience: What, where, and how wonderful?

Kaueˆ Machado Costa and Geoffrey Schoenbaum 



It is widely held that the hippocampus provides a cognitive map in which event-related information such as an object, location, and their significance is organized. However, how an organism’s motivational experience is coded in the hippocampus is mostly unknown. Here, we investigated whether the dorsal and intermediate regions of the hippocampus are differentially involved in representing changes in the motivational significance of a place. To investigate this, rats were run in tasks in which various rewards with different degrees of palatability were associated with the same locations while single units were simultaneously recorded along the dorsoventral axis of the hippocampus. Place cells in the intermediate hippocampus remapped immediately after motivational significance decreased and shifted their fields dynamically toward high-value locations. In contrast, place cells in the dorsal hippocampus were mostly unresponsive to the same manipulations. Our findings suggest that the motivational significance of place is uniquely coded in the intermediate hippocampus in goal- directed tasks.